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KMID : 0359919940130040934
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Korean Journal of Nephrology
1994 Volume.13 No. 4 p.934 ~ p.938
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An Overlapping Syndrome of IgA Nephropathy and Membranous Nephropathy Associated with Hepatitis B Surface Antigenemia
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Abstract
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Membranous nephropathy and IgA nephropathy are relatively common lesions among primary glomjerular diseases. However, a case of dglomerulonephritis combining the features of Iga nephropathy and membranous nephropathy has rarely been reported. We
are
reporting such a case with features of both IgA and membranous nephropathy associated with hepatitis B surface antigenemia. A 43-year-old man with hepatitis B surface antigenemia developed the nephrotic syndrome. Renal biopsy revealed a
glomerulonephritis with features of both IgA nephropathy and membranous nephropathy. Light microscopy showed mild, focal mesangial expansion and hypercellularity. Immunofluorescence microsocopy demonstrated both granular deposits of Iga in the
mesangium
and granular deposits of IgG along the capillary loops. On electron microscopy, electron dense deposits were identified not only in the paramesangdial area but also on the subepithelial side of glomerular basement membrane.
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KEYWORD
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